Transformation and Crystallization of Nhydrate/hydrate of Carbamazepine in Alcohol-water Solutions
نویسندگان
چکیده
The transformation and cooling crystallization of anhydrate form (form III) and dihydrate form (CBZH) of carbamazepine (CBZ) have been investigated in this work. The two forms were unambiguously characterized with powder X-ray diffraction, Fourier transform infrared spectroscopy, Raman spectroscopy, scanning electron microscopy and thermal analysis. The solubility of the two forms in various alcoholwater binary solutions was measured and delineated by van’t Hoff relationship. The enantiotropic transition temperatures of CBZ in these solutions were estimated from van’t Hoff plots. Solution-mediated transformation has been investigated to identify the relative stability of the two forms in different solutions.
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